Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation
V. T.-V. Dao, M. H. Elbatreek, S. Altenhöfer, A. I. Casas, M. P. Pachado, C. T. Neullens, U. Knaus, H. H. H. W. Schmidt
The paper demonstrates isoform-selective inhibition of NADPH oxidases (NOX1-NOX5) using advanced inhibitors and validates their efficacy in a human blood-brain barrier model.
bioRxiv · Jul 23, 2019Pharmacology & Toxicology