Pharmacology & ToxicologybioRxiv
Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation
V. T.-V. Dao, M. H. Elbatreek, S. Altenhöfer…·H. H. H. W. Schmidt
The paper demonstrates isoform-selective inhibition of NADPH oxidases (NOX1-NOX5) using advanced inhibitors and validates their efficacy in a human blood-brain barrier model.
DOI 10.1016/j.freeradbiomed.2019.12.038