Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity
P. Ray, K. Raghunathan, A. Ahsan, U. S. Allam, S. Shukla, V. Basrur, S. Veatch, T. S. Lawrence, M. K. Nyati, D. Ray
This paper identifies SMURF2-mediated ubiquitination of EGFR mutants as a mechanism enhancing receptor stability and TKI sensitivity.
bioRxiv · Apr 2, 2020 · PreprintCancer Biology