Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line
J. E. Mamatis, C. E. Gallardo-Flores, T. Walsh, U. Sangwan, C. C. Colpitts
This study identifies that cyclosporine A restricts HCoV-229E infection by inducing antiviral gene expression through interferon regulatory factor 1, independent of cyclophilin A/B or classical interferon responses.
bioRxiv · Jul 20, 2023Microbiology