T. Walsh

Rapid evolution of pesticide resistance via adaptation and interspecific introgression in a major North American crop pest

This study identifies two mechanisms of rapid pesticide resistance evolution in Helicoverpa zea: introgression from H. armigera and intraspecific adaptation.

Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line

This study identifies that cyclosporine A restricts HCoV-229E infection by inducing antiviral gene expression through interferon regulatory factor 1, independent of cyclophilin A/B or classical interferon responses.

Regulatory fine-tuning and horizontal gene transfer stabilize mobile colistin resistance

This study shows how regulatory evolution and horizontal gene transfer stabilize mcr-1 resistance in E. coli despite fitness costs.

Complex multiple introductions drive fall armyworm invasions into Asia and Australia

The paper uses population genomic analysis to trace multiple introductions of fall armyworm into Asia and Australia, showing human-assisted spread via trade and identifying genetic melting pot dynamics.

Effects of germline and somatic events in candidate BRCAness genes on breast-tumor signatures

The paper examines how germline and somatic events in BRCAness-related genes affect breast-tumor signatures, finding similarities between BRCA1/BRCA2 aberrations and other genes like ATR and BARD1.

Genomic balancing selection is key to the invasive success of the fall armyworm

This study shows genomic balancing selection restored heterozygosity in the Fall armyworm, enabling its global invasion success despite population bottlenecks.

A comparative 'omics approach to candidate pathogenicity factor discovery in the brain-eating amoeba Naegleria fowleri

This study uses -omics approaches to identify candidate pathogenicity factors in Naegleria fowleri by comparing it to its non-pathogenic relative Naegleria gruberi.

Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy

The paper introduces injection molded open microfluidic devices for coculture and microscopy, enabling study of cell interactions in standard cell culture workflows.

Multiple incursion pathways for Helicoverpa armigera in Brazil show its genetic diversity spreading in a connected world

The paper analyzes mtDNA haplotypes of Helicoverpa armigera in South America to show multiple incursion pathways, indicating independent introductions rather than a single origin.

PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

PHENOS provides a high-throughput method for measuring microbial growth on solid media, offering improved sensitivity and reproducibility compared to traditional techniques.