ImmunologybioRxivPreprint
RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury
J. C. Joshi, B. Joshi, C. Zhang…·D. Mehta
This study shows RGS2 limits IFNγ production in alveolar macrophages by inhibiting TLR4-Gαq signaling, reducing lung injury in mice and correlating with ARDS patient data.
DOI 10.1101/2023.09.22.559016