Author

J. C. Joshi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Mehta· 4 shared V. Vellingiri· 3 shared B. Joshi· 2 shared M. Anwar· 2 shared M. Z. Akhter· 2 shared S. Banerjee· 2 shared S. Pinho· 2 shared Y. Tsukasaki· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

D. Mehta

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche

V. Vellingiri, V. Avin BR, J. C. Joshi, M. Z. Akhter, M. Anwar, S. Banerjee, S. Dudek, Y. Tsukasaki, S. Pinho, D. Mehta

This study shows that endothelial ERG regulates neutrophil transcriptome to create an anti-inflammatory vascular niche, preventing excessive inflammation.

bioRxiv · May 2, 2024 · PreprintImmunology

RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury

J. C. Joshi, B. Joshi, C. Zhang, S. Banerjee, V. Vellingiri, V. A. B. Raghunathrao, L. Zhang, R. Amin, Y. Song, D. Mehta

This study shows RGS2 limits IFNγ production in alveolar macrophages by inhibiting TLR4-Gαq signaling, reducing lung injury in mice and correlating with ARDS patient data.

bioRxiv · Sep 22, 2023 · PreprintImmunology

Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate

M. Z. Akhter, P. Yazbeck, M. Tauseef, M. Anwar, F. Hossen, S. Datta, V. Vellingiri, J. C. Joshi, N. Srivastava, S. Lenzini, G. Zhou, J. Lee, M. K. Jain, J.-W. Shin, D. Mehta

This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.

bioRxiv · Apr 24, 2023 · PreprintCell Biology

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

Y. Tsukasaki, K. Bachmaier, J. C. Joshi, B. Joshi, P. T. Toth, Z. Hong, S. Nepal, M. Gunzer, J. Cho, D. Mehta, C. Tiruppathi, S. Pinho, J. Rehman, A. B. Malik

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

bioRxiv · Apr 19, 2021 · PreprintMicrobiology