Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells
O. Vivas, M. Baudot, S. Choi, V. A. Flores, L. F. Santana, C. M. Moreno
This study shows that aging reduces L-type calcium channel density, clustering, and open probability in cardiac pacemaker cells, leading to a slowdown in pacemaker rate, which can be reversed pharmacologically.
bioRxiv · Jun 22, 2022 · PreprintBiophysics