Author

L. F. Santana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Assay:electrophysiology· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

C. E. Clancy· 2 shared C. Matsumoto· 2 shared S. C. O'Dwyer· 2 shared Z. Fong· 2 shared B. Shui· 1 shared C. M. Moreno· 1 shared D. M. Small· 1 shared D. Manning· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

C. E. Clancy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

C. Matsumoto, S. C. O'Dwyer, D. Manning, G. Hernandez-Hernandez, P. Rhana, Z. Fong, D. Sato, C. E. Clancy, N. C. Vierra, J. S. Trimmer, L. F. Santana

This study shows that KV2.1 macro-clusters regulate sex-specific differences in CaV1.2 clustering and function in arterial myocytes by modulating phosphorylation at S590.

bioRxiv · Jun 27, 2023Physiology

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

G. Hernandez Hernandez, S. C. O'Dwyer, C. Matsumoto, M. Tieu, Z. Fong, P.-C. Yang, T. J. Lewis, L. F. Santana, C. E. Clancy

The paper develops a computational model to predict sex-specific responses to calcium channel blockers in arterial smooth muscle, revealing differences in ion channel regulation between male and female myocytes.

bioRxiv · Jun 24, 2023Physiology

Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells

O. Vivas, M. Baudot, S. Choi, V. A. Flores, L. F. Santana, C. M. Moreno

This study shows that aging reduces L-type calcium channel density, clustering, and open probability in cardiac pacemaker cells, leading to a slowdown in pacemaker rate, which can be reversed pharmacologically.

bioRxiv · Jun 22, 2022 · PreprintBiophysics

Genetically Engineered Strains for Combinatorial Cardiovascular Optobiology

F. K. Lee, J. C. Lee, B. Shui, S. Reining, M. Jibilian, D. M. Small, J. S. Jones, N. H. Allan-Rahill, M. R. Lamont, M. A. Rizzo, S. Tajada, M. F. Navedo, L. F. Santana, N. Nishimura, M. I. Kotlikoff

The paper introduces 21 genetically engineered mouse lines for combinatorial optogenetic studies in cardiovascular biology, enabling biallelic combination of effectors and sensors in multiple cell types.

bioRxiv · Jan 21, 2021Physiology