Structure-based design of a chemical probe set for the 5-HT5A serotonin receptor
A. L. Kaplan, R. T. Strachan, J. M. Braz, V. Craik, S. Slocum, T. Mangano, V. Amabo, H. R. O'Donnell, P. Lak, A. Basbaum, B. L. Roth, B. K. Shoichet
The paper develops a more selective chemical probe set for the 5-HT5A receptor, showing improved selectivity and reduced assay liabilities compared to the existing SB-699551 antagonist.
bioRxiv · Dec 6, 2021 · PreprintBiophysics