Author

J. M. Braz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Immunology· 2 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:behavioral assay· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. I. Basbaum· 5 shared B. K. Shoichet· 4 shared V. Craik· 3 shared A. Basbaum· 2 shared B. L. Roth· 2 shared D. S. Radchenko· 2 shared J. Benitez· 2 shared J. J. Irwin· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersImmunology

A. I. Basbaum

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Meningeal Regulatory T cell-derived enkephalin gates nociception

E. Midavaine, B. C. Moraes, J. Benitez, S. R. Rodriguez, J. M. Braz, N. P. Kochhar, W. L. Eckalbar, A. I. Domingos, J. E. Pintar, A. I. Basbaum, S. W. Kashem

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

bioRxiv · May 11, 2024 · PreprintImmunology

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

T. A. Tummino, C. Iliopoulos-Tsoutsouvas, J. M. Braz, E. S. O'Brien, R. M. Stein, V. Craik, N. K. Tran, S. Ganapathy, F. Liu, Y. Shiimura, F. Tong, T. C. Ho, D. S. Radchenko, Y. S. Moroz, S. R. Rosado, , B. K. Shoichet

The paper identifies a new cannabinoid-1 receptor agonist with reduced side effects through large library docking and experimental validation.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

W. W. S. Yue, L. Yuan, J. M. Braz, A. I. Basbaum, D. Julius

This study identifies that TRPV1 drugs alter core body temperature through central projections of sensory neurons, not peripheral vascular effects.

bioRxiv · May 9, 2022 · PreprintPhysiology

Structure-based design of a chemical probe set for the 5-HT5A serotonin receptor

A. L. Kaplan, R. T. Strachan, J. M. Braz, V. Craik, S. Slocum, T. Mangano, V. Amabo, H. R. O'Donnell, P. Lak, A. Basbaum, B. L. Roth, B. K. Shoichet

The paper develops a more selective chemical probe set for the 5-HT5A receptor, showing improved selectivity and reduced assay liabilities compared to the existing SB-699551 antagonist.

bioRxiv · Dec 6, 2021 · PreprintBiophysics

IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis

M. S. Fassett, J. M. Braz, C. A. Castellanos, A. W. Schroeder, M. Sadeghi, D. J. Mar, C. J. Zhou, J.-S. Shin, A. I. Basbaum, K. M. Ansel

This study shows IL-31 limits allergic skin inflammation but is essential for itch sensation in dermatitis, uncoupling inflammation from itch.

bioRxiv · May 12, 2021 · PreprintImmunology

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

A. Alon, J. Lyu, J. M. Braz, T. A. Tummino, V. Craik, M. J. O'Meara, C. M. Webb, D. S. Radchenko, Y. S. Moroz, X.-P. Huang, Y. Liu, B. L. Roth, J. J. Irwin, A. I. Basbaum, B. K. Shoichet, A. C. Kruse

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

bioRxiv · Apr 29, 2021Pharmacology & Toxicology