Modulation of macrophage defense responses by Mycobacterial persistence protein MprA (Rv0981) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactions
K. Bhattacharyya, U. Bandopadhyay, A. Singh, A. Prakash, V. Nemaysh, S. Jain, M. Varma-Basil, A. M. Lynn, M. Bose, P. M. Luthra, K. Natarajan, V. Brahmachari
This study shows that the MprA variant G70S in M. tuberculosis reduces phago-lysosome fusion and increases immune suppressive cytokines in THP-1 macrophages, supporting pathogen persistence.
bioRxiv · Apr 27, 2020 · PreprintMicrobiology