Author

K. Natarajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 3 Assay:structural biology· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2

Frequent Co-Authors

D. H. Margulies· 2 shared J. Ahmad· 2 shared J. Jiang· 2 shared L. F. Boyd· 2 shared A. C. F. Leung· 1 shared A. D. Axtman· 1 shared A. Devarajan· 1 shared A. E. Burgess· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

D. H. Margulies

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Author profile →

8 papers

Recent·Most cited

Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells

D. Dutta, S. M. Rajam, P. C. Varghese, M. B. Shirude, K. M. Syed, A. Devarajan, K. Natarajan

This study identifies APLF as a kinase in mouse embryonic stem cells that regulates centrosome number through PLK4 phosphorylation and FHA domain ATP binding.

bioRxiv · Feb 6, 2024Biochemistry

Experimental structures of antibody/MHC-I complexes reveal details of epitopes overlooked by computational prediction

L. F. Boyd, J. Jiang, J. Ahmad, K. Natarajan, D. H. Margulies

X-ray structures of anti-MHC-I/MHC-I complexes define epitopes overlooked by computational prediction.

bioRxiv · Dec 1, 2023Immunology

Dynamic Expedition of Leading Mutations in SARS-CoV-2 Spike Glycoproteins

M. Hasan, Z. He, M. Jia, A. C. F. Leung, K. Natarajan, W. Xu, S. Q. Yap, F. Zhou, S. Chen, H. Su, K. Zhu, H. Su

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

bioRxiv · Dec 29, 2021Evolutionary Biology

Synthetic nanobody-SARS-CoV-2 receptor-binding domain structures identify distinct epitopes

J. Ahmad, J. Jiang, L. F. Boyd, K. Natarajan, D. H. Margulies

The paper reports X-ray structures of synthetic nanobodies bound to SARS-CoV-2 RBD, revealing CDR loop interactions and epitope recognition details.

bioRxiv · Jan 27, 2021Immunology

Modulation of macrophage defense responses by Mycobacterial persistence protein MprA (Rv0981) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactions

K. Bhattacharyya, U. Bandopadhyay, A. Singh, A. Prakash, V. Nemaysh, S. Jain, M. Varma-Basil, A. M. Lynn, M. Bose, P. M. Luthra, K. Natarajan, V. Brahmachari

This study shows that the MprA variant G70S in M. tuberculosis reduces phago-lysosome fusion and increases immune suppressive cytokines in THP-1 macrophages, supporting pathogen persistence.

bioRxiv · Apr 27, 2020 · PreprintMicrobiology

STUDY ON THE INFLAMMATORY RESPONSE OF PMMA/POLYSTYRENE/SILICA NANOCOMPOSITE MEMBRANES FOR DRUG DELIVERY AND DENTAL APPLICATIONS

S. S. Saravanabhavan, K. NATARAJAN, S. Elumalai, S. Zsolt, M. K. SELVAM, M. Janakiraman, N. Jonna, K. V. Palaniappan, K. PALANI, P. Venkatesan, B. Natesan

The paper investigates the inflammatory response of PMMA/polystyrene/silica composite membranes and finds no inflammation in samples with equal PMMA-PS concentrations.

bioRxiv · Dec 17, 2018Scientific Communication & Education

Substrate binding allosterically relieves autoinhibition of the TRIB1 pseudokinase

S. A. Jamieson, Z. Ruan, A. E. Burgess, J. R. Curry, H. D. McMillan, J. L. Brewster, A. K. Dunbier, A. D. Axtman, K. Natarajan, P. D. Mace

The paper shows that substrate binding to TRIB1 pseudokinase induces allosteric changes enabling complex formation with COP1 ubiquitin ligase.

bioRxiv · May 3, 2018Biochemistry

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

J. Pramanik, X. Chen, G. Kar, T. Gomes, J. Henriksson, Z. Miao, K. Natarajan, A. N. J. McKenzie, B. Mahata, S. A. Teichmann

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.

bioRxiv · Dec 15, 2017Cell Biology