Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
G. Taylor, H.-I. Huang, B. E. Fee, N. Youssef, V. Cantillana, A. Schoenborn, A. R. Rogala, A. F. Buckley, B. A. Vallance, A. S. Gulati, G. E. Hammer
This study shows that Irgm1 deficiency causes myeloid cell dysfunction in the colon and increased susceptibility to Citrobacter rodentium infection, independent of intracellular killing.
bioRxiv · Mar 26, 2019Immunology