Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6
F. M. Ranaivoson, V. Crozet, M. Benoit, A. A. Mohammed Khalid, C. Kikuti, H. Sirkia, A. El Marjou, A. Asenjo, H. Sosa, C. Schmidt, S. Rosenfeld, A. Houdusse
This paper presents the first high-resolution structure of Kif20A's motor domain, revealing structural features and allostery mechanisms that explain its atypical motility and ATPase activity.
bioRxiv · Nov 10, 2022 · PreprintBiochemistry