The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells
D. Blackburn, K. Sahinyan, A. Hernnandez Corchado, F. Lazure, V. Richard, L. Raco, R. Zahedi, C. Borchers, C. Lepper, H. Kawabe, A. Jahani-asl, H. S. Najafabadi, V. D. Soleimani
This study identifies the PAX7/NEDD4L axis as a checkpoint regulating quiescence in muscle stem cells, showing that Nedd4L deletion impairs quiescence and promotes activation.
bioRxiv · May 10, 2023 · PreprintCell Biology