Single-cell analysis reveals cellular heterogeneity and molecular determinants of hypothalamic leptin-receptor cells
Nefeli Kakava-Georgiadou, Jeppe F. Severens, Anja Moltke Jørgensen, Iris Stoltenborg, Keith M. Garner, Mieneke C. M. Luijendijk, V. Drkelic, Roland E. van Dijk, Suzanne L. Dickson, Tune H. Pers, Onur Başak, Roger A.H. Adan
The paper uses scRNA-seq to analyze LepR cells in the hypothalamus, identifying eight neuronal clusters and 17 non-neuronal populations, and finds enrichment of obesity GWAS signals in multiple clusters.
bioRxiv · Jul 23, 2020 · PreprintNeuroscience