Roger A.H. Adan

The paper identifies FOXP1 as a key regulator of oxytocin neuron differentiation and shows its role in reducing AVP and OXT neuron abundance in knockout mice.

This study identifies a prefrontal cortex-lateral hypothalamus circuit that mediates stress-driven increased food intake in mice.

This paper introduces LifeCamp, a high-speed calcium lifetime sensor developed using RALISED, enabling accurate measurement of baseline and transient calcium levels in neurons.

The paper develops FLIPR, a system for absolute fluorescence lifetime measurement in mice, revealing spatial and temporal variations in dopamine signaling.

The paper identifies distinct VTA neuronal ensembles for reward and stress and shows their necessity for adaptive behaviors.

This study investigates the role of NAc D1 and D2 neurons in balancing feeding and exercise-mediated energy expenditure in mice, finding that manipulating these neurons affects energy balance and weight.

The paper integrates single-cell transcriptomic data with genome-wide association studies to identify neuronal cell types consistently implicated in neuropsychiatric disorders.

This study shows that olfactory cues of palatable food increase meal frequency and chow overconsumption in sated rats, involving the orexigenic ghrelin system in the hypothalamic arcuate nucleus.

The paper identifies genetic differences in BMI between tall and short individuals using UK Biobank data, finding height-specific loci and differential effects on BMI and related traits.

The paper uses scRNA-seq to analyze LepR cells in the hypothalamus, identifying eight neuronal clusters and 17 non-neuronal populations, and finds enrichment of obesity GWAS signals in multiple clusters.

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

This study investigates how hyperdopaminergic states affect decision-making in rats by examining the role of VTA projections to the nucleus accumbens and prefrontal cortex.

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.