Author

V. E. Cruz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

C. S. Weirich· 2 shared J. P. Erzberger· 2 shared F. E. Demircioglu· 1 shared G. G. Gundersen· 1 shared K. Sekulski· 1 shared N. Peddada· 1 shared S. Antoku· 1 shared S. M. Lim· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

C. S. Weirich

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Author profile →

4 papers

Recent·Most cited

The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis

V. E. Cruz, C. S. Weirich, N. Peddada, J. P. Erzberger

This study identifies Dbp10/DDX54's role in forming the peptidyl transferase center during 60S ribosome biogenesis using cryo-EM.

bioRxiv · Nov 1, 2023Biophysics

rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly

K. Sekulski, V. E. Cruz, C. S. Weirich, J. P. Erzberger

This study shows that rRNA methylation by Spb1 regulates Nog2 GTPase activity during 60S ribosome assembly, revealing a kinetic checkpoint mechanism.

bioRxiv · May 25, 2022Biophysics

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins

S. M. Lim, V. E. Cruz, S. Antoku, G. G. Gundersen, T. Schwartz

The paper reports the crystal structure of FHOD1-Nes2G complexes, revealing that the FH3 domain of formins binds spectrin repeats and suggests overlapping functions of Nesprin1/2 in actin-bundle recruitment for nuclear movement.

bioRxiv · Jun 19, 2020Biochemistry

Structural analysis of different LINC complexes reveals distinct binding modes

V. E. Cruz, F. E. Demircioglu, T. U. Schwartz

The paper solves high-resolution crystal structures of human SUN2 complexes with different KASH peptides, revealing distinct binding modes and structural elements critical for KASH interaction.

bioRxiv · Jun 19, 2020Biochemistry