Author

V. J. Lowe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:deconvolution· 1 Approach:deep learning· 1

Frequent Co-Authors

G. L. Curran· 2 shared K. K. Kandimalla· 2 shared L. Wang· 2 shared P. H. Min· 2 shared A. T. Nguyen· 1 shared B. F. Boeve· 1 shared B. J. Burkett· 1 shared C. G. Schwarz· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

G. L. Curran

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Amyloid Beta Peptides Inhibit Glucose Transport at the Blood-brain Barrier by Disrupting Insulin-Akt Pathway in Alzheimer's Disease

L. Wang, G. L. Curran, P. H. Min, L. Li, V. J. Lowe, K. K. Kandimalla

This study shows that amyloid-beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-Akt pathway and increasing TXNIP expression.

bioRxiv · Nov 21, 2022 · PreprintPharmacology & Toxicology

Deconvolution of plasma pharmacokinetics from dynamic heart imaging data obtained by SPECT/CT imaging

Z. Wang, L. Wang, M. Ebbini, G. L. Curran, P. H. Min, R. A. Siegel, V. J. Lowe, K. K. Kandimalla

This paper develops a compartmental model to deconvolve plasma pharmacokinetics from dynamic heart imaging data, enabling accurate analysis of radiotracer kinetics without invasive plasma sampling.

bioRxiv · Nov 17, 2022 · PreprintPharmacology & Toxicology

Synthesizing Images of Tau Pathology from Cross-modal Neuroimaging using Deep Learning

J. Lee, B. J. Burkett, H.-K. Min, M. L. Senjem, E. Dicks, N. Corriveau-Lecavalier, C. T. Mester, H. J. Wiste, E. S. Lundt, M. E. Murray, A. T. Nguyen, R. R. Reichard, H. Botha, J. Graff-Radford, L. R. Barnard, , D. T. Jones

This study uses a CNN to impute tau PET images from cross-modal neuroimaging data, finding that FDG-based models improve classification of tau positivity and diagnostic groups.

bioRxiv · Sep 7, 2022Bioengineering