D. T. Jones

Microbiome-Derived Metabolites Shape CD4⁺ T-Cell Differentiations and Immune Aging in Chronic HIV-1 Infection

This study identifies microbiome-derived metabolites, particularly p-cresol sulfate, that alter CD4 T-cell metabolism and promote immune aging in HIV-1 infection.

Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5

This study determines the structure of PP2A/B55 inhibited by IER5-N50 and shows its role in suppressing pTau dephosphorylation and KRT1 expression.

Synthesizing Images of Tau Pathology from Cross-modal Neuroimaging using Deep Learning

This study uses a CNN to impute tau PET images from cross-modal neuroimaging data, finding that FDG-based models improve classification of tau positivity and diagnostic groups.

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.