mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
L. M. Riedmayr, K. S. Hinrichsmeyer, S. B. Thalhammer, N. Karguth, S. Boehm, D. M. Mittas, V. J. Weber, D. Otify, V. Splith, M. Bruemmer, N. Boon, J. Wijnholds, V. Mehlfeld, S. Michalakis, S. Fenske, , E. Becirovic
This paper introduces REVeRT, a dual AAV vector system using mRNA trans-splicing for efficient gene delivery and editing, showing improved reconstitution and therapeutic potential in a mouse model.
bioRxiv · Feb 7, 2023Bioengineering