Gaucher Disease Protects Against Tuberculosis
J. Fan, V. L. Halre, L. T. Lelieveld, L. J. Whitworth, E. M. Busch-Nentwich, M. Troll, P. H. Edelstein, T. M. Cox, F. J. Roca, J. M. F. G. Aerts, L. Ramakrishnan
This paper shows that the GBA1 N370S mutation, common in Ashkenazi Jews, protects against tuberculosis by enhancing macrophage microbicidal activity through glucosylsphingosine.
bioRxiv · Oct 16, 2022Microbiology