Author

V. N. Manoharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:synaptic & neural circuits· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

R. F. Garmann· 3 shared A. M. Goldfain· 2 shared F. F. Vasquez· 2 shared C. E. Beren· 1 shared C. M. Knobler· 1 shared C. R. Tanimoto· 1 shared D. A. Villarreal· 1 shared H. K. Dhaliwal· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

R. F. Garmann

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Measuring intramolecular connectivity in long RNA molecules using two-dimensional DNA patch-probe arrays

T. K. Chiang, O. Kimchi, H. K. Dhaliwal, D. A. Villarreal, F. F. Vasquez, V. N. Manoharan, M. P. Brenner, R. F. Garmann

This paper introduces a method to measure intramolecular connectivity in long RNA molecules using DNA patch-probe arrays and validates it on STMV RNA, revealing coexisting global and local structures.

bioRxiv · Mar 12, 2023Biophysics

Single-particle studies of the effects of RNA-protein interactions on the self-assembly of RNA virus particles

R. F. Garmann, A. M. Goldfain, C. R. Tanimoto, C. E. Beren, F. F. Vasquez, C. M. Knobler, W. M. Gelbart, V. N. Manoharan

This study uses interferometric scattering microscopy to observe the self-assembly of brome mosaic virus particles, showing that RNA-protein interactions control nucleation rates while protein-protein interactions drive growth.

bioRxiv · May 9, 2022Biophysics

Measurements of the self-assembly kinetics of individual viral capsids around their RNA genome

R. F. Garmann, A. M. Goldfain, V. N. Manoharan

This study directly observes the self-assembly kinetics of individual bacteriophage MS2 capsids around RNA using interferometric scattering microscopy, revealing a nucleation-and-growth pathway and constraints on critical nucleus size.

bioRxiv · Aug 10, 2018Biophysics