Cancer BiologybioRxivPreprint
NOTCH1 drives immune-escape mechanisms in B cell malignancies
M. Mangolini, A. Maiques-Diaz, S. Charalampopoulou…·I. Ringshausen
This study shows NOTCH1 mutations in B cell malignancies promote immune escape by upregulating PD-L1 and silencing HLA-class II, leading to poor clinical outcomes.
DOI 10.1101/2021.04.10.439192