Author

V. N. Timonina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Tretiakov· 2 shared K. Gunbin· 2 shared K. PopadiniD· 2 shared A. G. Mikhailova· 1 shared A. Goncharov· 1 shared A. V. Kuzmin· 1 shared B. Efimenko· 1 shared C. R. Haag· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersEvolutionary Biology

E. Tretiakov

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2 papers

Recent·Most cited

Improving genome quality through artificial truncating purifying selection using heat shock: case of carps

A. V. Kuzmin, E. Vinogradov, D. Balashov, E. Kozenkova, D. Iliushchenko, A. G. Mikhailova, N. Patlay, E. Zakharenko, I. I. Kozenkov, I. Ptashnik, V. N. Timonina, E. Tretiakov, Y. Galimov, C. R. Haag, B. Efimenko, , K. Popadin

The paper investigates using heat shock to induce purifying selection in carp to reduce deleterious mutations, finding that fitness drops more in mutated lines but with weak and unstable effects.

bioRxiv · Jan 20, 2023 · PreprintEvolutionary Biology

Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scales

V. N. Timonina, E. Tretiakov, A. Goncharov, K. Gunbin, J. Fellay, K. Popadin

This study shows that HSP90 buffering of slightly deleterious variants affects molecular evolution across species, tissues, and genes, with implications for predicting variant effects in the human genome.

bioRxiv · Nov 11, 2022 · PreprintEvolutionary Biology