K. Gunbin

Improving genome quality through artificial truncating purifying selection using heat shock: case of carps

The paper investigates using heat shock to induce purifying selection in carp to reduce deleterious mutations, finding that fitness drops more in mutated lines but with weak and unstable effects.

Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scales

This study shows that HSP90 buffering of slightly deleterious variants affects molecular evolution across species, tissues, and genes, with implications for predicting variant effects in the human genome.

Analysis of Skin Cancers from Xeroderma Pigmentosum Patients Reveals Heterogeneous UV-Induced Mutational Profiles Shaped by DNA Repair

The paper analyzes skin cancer genomes from Xeroderma Pigmentosum patients to show how NER activity shapes mutation rates and reveals POLH's role in bypassing UV-induced DNA lesions.

Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers

The paper analyzes SARS-CoV-2 mutagenesis, showing C>U and G>U biases drive amino-acid substitutions from CG-rich losers to U-rich gainers, with implications for vaccine design.

Mammalian mitochondrial mutational spectrum as a hallmark of cellular and organismal aging.

The paper investigates mtDNA mutational spectra across species and tissues, finding a correlation between AH>GH substitutions and longevity, suggesting it as a potential oxidative damage signature in mtDNA.

A>G substitutions on a heavy chain of mitochondrial genome marks an increased level of aerobic metabolism in warm versus cold vertebrates .

The paper examines A>G substitutions in mtDNA across vertebrates, finding higher rates in warm-blooded species, suggesting temperature influences oxidative damage and mutational patterns.

Mitochondrial pseudogenes suggest repeated inter-species hybridization in hominid evolution.

The paper identifies mitochondrial pseudogenes in hominids, suggesting repeated inter-species hybridization during human evolution.