PhysiologybioRxiv
DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts
M. Shumliakivska, G. Luxan, I. Hemmerling…·S. Dimmeler
This study shows that DNMT3A mutations in hematopoietic cells drive cardiac fibrosis by activating fibroblasts through paracrine signaling, contributing to heart failure progression.