Author

G. Luxan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

S. Dimmeler· 5 shared D. John· 4 shared A. Fischer· 3 shared M. Muhly-Reinholz· 3 shared S. Guenther· 3 shared W. T. Abplanalp· 3 shared A. M. Zeiher· 2 shared A. Zeiher· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersPhysiology

S. Dimmeler

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Author profile →

5 papers

Recent·Most cited

Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart

A. Tamiato, L. S. Tombor, A. Fischer, M. Muhly-Reinholz, L. R. Vanicek, B. N. Togru, J. Neitz, S. F. Glaser, M. Merten, D. Rodriguez Morales, J. Kwon, S. Klatt, B. Schuhmacher, S. Guenther, W. T. Abplanalp, , G. Luxan

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

bioRxiv · Dec 8, 2023Physiology

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

M. Shumliakivska, G. Luxan, I. Hemmerling, W. T. Abplanalp, X. Li, M. Scheller, C. Muller-Tidow, F. Leuschner, B. Schuhmacher, A. Debes, S.-F. Glaser, M. Muhly Reinholz, K. Kirschbaum, J. Hoffmann, E. Nagel, , S. Dimmeler

This study shows that DNMT3A mutations in hematopoietic cells drive cardiac fibrosis by activating fibroblasts through paracrine signaling, contributing to heart failure progression.

bioRxiv · Jan 7, 2023Physiology

Ageing impairs the neuro-vascular interface in the heart

J. Wagner, L. Tombor, P. Malacarne, L.-M. Kettenhausen, J. Panthel, M. Cipca, K. Stilz, A. Fischer, M. Muhly-Reinholz, W. Abplanalp, D. John, G. Buchmann, S. Angerdohr, E. Amir, K. Scherschel, , S. Dimmeler

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

bioRxiv · Jul 29, 2022 · PreprintPhysiology

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

D. Bojkova, J. Wagner, M. Shumliakivska, G. Aslan, U. Saleem, A. Hansen, G. Luxan, S. Guenther, M. D. Pham, J. Krishnan, P. Harter, U. Ermel, A. S. Frangakis, A. Zeiher, H. Milting, , S. Dimmeler

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

bioRxiv · Jun 1, 2020Cell Biology

Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche

J. Hoffmann, G. Luxan, W. T. Abplanalp, S.-F. Glaser, T. Rasper, A. Fischer, M. Muhly-Reinholz, D. John, B. Assmus, A. M. Zeiher, S. Dimmeler

This study investigates how post-myocardial infarction heart failure affects the bone vascular niche, showing age-independent loss of type H endothelium and increased inflammatory gene expression in human bone marrow endothelium.

bioRxiv · May 29, 2020Cell Biology