CXCR4 signaling is counteracted by the naturally occurring CXCR4 antagonist EPI-X 4 in Waldenstrom Macroglobulinemia
L. M. Kaiser, M. Harms, D. Sauter, V. P. Rawat, M. Glitscher, E. Hildt, D. Tews, Z. Hunter, J. Muench, C. Buske
This study shows that the natural CXCR4 antagonist EPI-X4 inhibits Waldenstrom Macroglobulinemia cell growth and migration, with optimized derivatives showing enhanced efficacy.
bioRxiv · Oct 19, 2020 · PreprintCancer Biology