Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress
H. C. Leeson, J. Aguado, C. Gomez-Inclan, H. K. Chaggar, A. Taherian Fard, Z. Hunter, M. F. Lavin, A. Mackay-Sim, E. J. Wolvetang
This study uses patient-derived iPSCs and organoids to show mitochondrial dysfunction and oxidative stress in AT, which can be mitigated by ATM correction or antioxidants.
bioRxiv · Jan 29, 2024Cell Biology