The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
J. Luban, R. Sattler, E. Muhlberger, J. D. Graci, L. Cao, M. Weetall, C. Trotta, J. M. Colacino, S. Bavari, C. Strambio-De-Castillia, E. L. Suder, Y. Wang, V. Soloveva, K. Cintron-Lue, N. A. Naryshkin, , S. Peltz
This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.
bioRxiv · Aug 5, 2020Immunology