E. Muhlberger

PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

Isolation and genome characterization of Lloviu virus from Italian Schreibers bent-winged bats

The paper isolates and characterizes Lloviu virus from Italian bats, establishing an infectious isolate and conducting evolutionary analysis.

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

This study shows CD169 enables ACE2-independent SARS-CoV-2 entry in macrophages, leading to restricted viral replication and pro-inflammatory cytokine production.

DISTINCTIVE FEATURES OF THE RESPIRATORY SYNCYTIAL VIRUS PRIMING LOOP COMPARED TO OTHER NON-SEGMENTED NEGATIVE STRAND RNA VIRUSES

This study identifies Pro1261 in the RSV polymerase as critical for RNA synthesis initiation, unlike a corresponding residue in a filovirus polymerase.

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

The paper investigates SARS-CoV2-induced inflammatory responses in monocytes using in vitro co-cultures, identifying a virus-specific gene cluster distinct from other viruses.

Reservoir host studies of Lloviu virus: first isolation, sequencing and serology in Schreiber's bats in Europe

This study isolates and characterizes Lloviu virus from Schreiber's bats in Europe, showing its ability to infect human and monkey cells and suggesting potential spillover risks.

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2

This study identifies CD209L/L-SIGN and CD209/DC-SIGN as alternative receptors for SARS-CoV-2, capable of mediating virus entry into human cells, particularly in tissues with low ACE2 expression.