TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to circulating, non-infectious immature dengue virus particles
J. A. Aguilar Briseno, L. Ramos Pereira, M. van der Laan, M. Pauzuolis, B. M. ter Ellen, V. Upasani, J. Moser, L. C. de Souza Ferreira, J. M. Smit, I. A. Rodenhuis-Zybert
This study shows that immature dengue virus particles activate the TLR2 axis in PBMCs, driving inflammation and endothelial activation, with TLR2 playing a role in both initiating and resolving inflammation.
bioRxiv · Apr 7, 2022Immunology