Author

J. M. Smit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

I. A. Rodenhuis-Zybert· 5 shared D. P. I. van de Pol· 3 shared E. M. Bouma· 3 shared J. Moser· 3 shared B. M. ter Ellen· 2 shared J. A. Aguilar Briseno· 2 shared M. Pauzuolis· 2 shared n. dinesh kumar· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersMicrobiology

I. A. Rodenhuis-Zybert

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

BNIP3 regulates Chikungunya virus infection independently of autophagy and cell death

L. Echavarria-Consuegra, n. dinesh kumar, M. Mauthe, d. van de pol, F. Reggiori, J. M. Smit

This study identifies BNIP3 as an antiviral factor that inhibits Chikungunya virus infection independently of autophagy and cell death, acting during the early stages of the viral cycle.

bioRxiv · Aug 22, 2022 · PreprintMicrobiology

TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to circulating, non-infectious immature dengue virus particles

J. A. Aguilar Briseno, L. Ramos Pereira, M. van der Laan, M. Pauzuolis, B. M. ter Ellen, V. Upasani, J. Moser, L. C. de Souza Ferreira, J. M. Smit, I. A. Rodenhuis-Zybert

This study shows that immature dengue virus particles activate the TLR2 axis in PBMCs, driving inflammation and endothelial activation, with TLR2 playing a role in both initiating and resolving inflammation.

bioRxiv · Apr 7, 2022Immunology

Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery

V. Mangala Prasad, J. S. Blijleven, J. M. Smit, K. K. Lee

This study visualizes the membrane fusion process of Chikungunya virus using cryo-electron tomography, revealing conformational changes and structural features of the fusion machinery.

bioRxiv · Mar 12, 2022 · PreprintBiophysics

Resveratrol And Pterostilbene Potently Inhibit SARS-CoV-2 Replication In Vitro

B. M. ter Ellen, N. Dinesh Kumar, E. M. Bouma, B. Troost, D. P. I. van de Pol, H. H. van der Ende-Metselaar, L. Apperloo, D. van Gosliga, M. van den Berge, M. C. Nawijn, P. H. J. van der Voort, J. Moser, I. A. Rodenhuis-Zybert, J. M. Smit

This study shows resveratrol and pterostilbene inhibit SARS-CoV-2 replication in vitro in multiple cell types, with long-lasting antiviral effects.

bioRxiv · Sep 24, 2020 · PreprintMicrobiology

Chikungunya virus requires an intact microtubule network for efficient viral genome delivery

T. E. Hoornweg, E. M. Bouma, D. P. I. van de Pol, I. A. Rodenhuis-Zybert, J. M. Smit

This study shows that Chikungunya virus requires an intact microtubule network for efficient viral genome delivery during cell entry, enhancing infection.

PLOS Neglected Tropical Diseases · Aug 7, 2020Peer-reviewedMicrobiology

Rewiring PBMC responses to prevent CHIKV infection-specific monocyte subset redistribution and cytokine responses

J. A. Aguilar Briseno, M. Ruiz Silva, J. Moser, M. Pauzuolis, J. M. Smit, I. A. Rodenhuis-Zybert

This study investigates how CHIKV infection affects monocyte subsets and cytokine responses, showing that infectious CHIKV increases intermediate and non-classical monocytes while reducing classical monocytes.

bioRxiv · Jun 4, 2020 · PreprintImmunology

Serotonergic drugs inhibit CHIKV infection at different stages of the cell entry pathway

E. M. Bouma, D. P. I. van de Pol, I. D. Sanders, I. A. Rodenhuis-Zybert, J. M. Smit

This study identifies serotonergic drugs that inhibit CHIKV infection by targeting early stages of the replication cycle, specifically before RNA translation and genome replication.

bioRxiv · Mar 24, 2020Microbiology