Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program
C. Byerly, S. Mitra, L. L. Patterson, N. A. Pittner, T. S. Velayutham, S. Paessler, V. Veljkovic, J. W. McBride
This study identifies a TRP120 SLiM ligand mimetic from Ehrlichia chaffeensis that activates Hedgehog signaling to induce BCL-2 expression and inhibit apoptosis, facilitating bacterial infection.
bioRxiv · Feb 8, 2022Microbiology