Increased axon initial segment length results in increased Na+ currents in spinal motoneurones at symptom onset in the G127X SOD1 mouse model of Amyotrophic Lateral Sclerosis.
H.S. Jørgensen, Dennis Bo Jensen, K. P. Dimintiyanova, V.S. Bonnevie, Anne Hedegaard, Janna Lehnhoff, Mihai Moldovan, L. Grøndahl, Claire Francesca Meehan
The paper investigates excitability changes in G127X SOD1 mice at symptom onset, finding increased Na+ currents and longer axon initial segments (AISs) in spinal motoneurones.
Neuroscience · Nov 24, 2020Peer-reviewedNeuroscience