Cytokine-bearing Bacterial Outer Membrane Vesicles with Empowered Efficacy in Intratumoral Immunotherapy
Riccardo Corbellari, Michele Tomasi, Mattia Benedet, Assunta Gagliardi, Rubens Begaj, Ilaria Zanella, Silvia Tamburini, Elena Caproni, Enxhi Shaba, Gabriele Di Lascio, Valeria Facchini, Chiara Baraldi, Gaia Gambini, Alvise Berti, Andrea Lunardi, , Alberto Grandi
This study engineers bacterial outer membrane vesicles with cytokines to enhance antitumor efficacy in intratumoral immunotherapy, achieving tumor eradication in over 95% of mice.
bioRxiv · Apr 6, 2026 · PreprintCancer Biology