Andrea Lunardi

The paper uses spatial single-cell proteomics to map multicellular niches in primary prostate cancer, identifying prognostic cell types and niches beyond Gleason grading.

This study engineers bacterial outer membrane vesicles with cytokines to enhance antitumor efficacy in intratumoral immunotherapy, achieving tumor eradication in over 95% of mice.

This study identifies the YAP/NNMT axis as a driver of innate sensitivity to NAMPT inhibition in stem-like mesenchymal prostate cancer, suggesting NNMT as a biomarker for NAD+-targeting therapies.

This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.