Paraquat Licences α-Synuclein to Trigger NLRP3-Dependent Pyroptosis in Microglia
Yuzhihan Cao, Vandana Deora, Nemat Khan, Avril A. B. Robertson, Kate Schroder, Matthew A. Cooper, Trent M. Woodruff, Eduardo A. Albornoz
This study shows paraquat enables α-synuclein to trigger NLRP3-dependent pyroptosis in microglia, linking environmental toxins to Parkinson's disease pathogenesis.
bioRxiv · Jul 23, 2025 · PreprintNeuroscience