Discovery of the Phosphonate Flavophos Produced by Burkholderia
Max A. Simon, Josseline S. Ramos‐Figueroa, Vanessa Reyes Lopez, Chayanid Ongpipattanakul, Lingyang Zhu, Constantin Giurgiu, Zoe A. Hoffpauir, Audrey L. Lamb, Satish K. Nair, Wilfred A. van der Donk
This study identifies a new phosphonate antibiotic, flavophos, produced by Burkholderia, which inhibits lumazine synthase and confers resistance when expressed in E. coli.
Journal of the American Chemical Society · Apr 27, 2026Peer-reviewedBiochemistry