Josseline S. Ramos‐Figueroa

Discovery of the Phosphonate Flavophos Produced by Burkholderia

This study identifies a new phosphonate antibiotic, flavophos, produced by Burkholderia, which inhibits lumazine synthase and confers resistance when expressed in E. coli.

The Biosynthetic Pathway to the Pyrroloiminoquinone Marine Natural Product Ammosamide C

This paper identifies the biosynthetic pathway for ammosamide C, revealing novel enzymatic steps and roles for PEARLs beyond traditional PTMs.

Aminoacyl-tRNA specificity of a ligase catalyzing non-ribosomal peptide extension

This study investigates the substrate specificity of the PEARL BhaBCAla, showing it can use non-cognate amino acids and tRNAs for peptide extension, with efficiency depending on both amino acid and tRNA features.

Unexpected transformations during pyrroloiminoquinone biosynthesis

This study reveals the complexity of pyrroloiminoquinone biosynthesis by identifying four additional enzymes that correct a previously proposed pathway and show that amino groups come from glycine, asparagine, and leucine.