Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation in a neprilysin-independent manner
Declan Williams, Bei Qi Yan, Hansen Wang, Logine Negm, Christopher Sackmann, Claire E. Verkuyl, Vanessa Rezai-Stevens, Shehab Eid, Christine Sato, Joel C. Watts, Holger Wille, Gerold Schmitt‐Ulms
This study shows that somatostatin reduces Aβ plaque formation in aged mice by inhibiting Aβ aggregation, independent of neprilysin.
bioRxiv · Sep 26, 2022 · PreprintNeuroscience