Shehab Eid

This paper demonstrates that delivering a protective prion protein variant via gene therapy extends survival in a prion disease mouse model.

The paper investigates ER and perinuclear space dilations in prion-infected mice and identifies TRPV2 as a contributor to this phenomenon, which may relate to spongiform degeneration.

The paper compares the interactomes of mouse and bank vole prion proteins in brain tissue to determine if differences in protein interactions explain the bank vole's susceptibility to prions.

The paper identifies key amino acid residues in bank vole prion protein (BVPrP) that enable it to act as a universal prion acceptor, revealing molecular mechanisms for cross-species prion replication.

This study shows that somatostatin reduces Aβ plaque formation in aged mice by inhibiting Aβ aggregation, independent of neprilysin.