Author

Christopher Sackmann

University of TorontoORCID 0000-0002-1273-6731Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Declan WilliamsiD· 3 shared Gerold Schmitt‐UlmsiD· 3 shared Shehab EidiD· 3 shared Thomas Zerbes· 2 shared Xinzhu WangiD· 2 shared Bei Qi Yan· 1 shared Christine SatoiD· 1 shared Claire E. VerkuyliD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Declan WilliamsORCID

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3 papers

Recent·Most cited

NeuroscienceActa NeuropathologicaPeer-reviewedJun 23, 2025

Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice

Wenda Zhao, Shehab Eid, Christopher Sackmann…·Gerold Schmitt‐Ulms

The paper investigates ER and perinuclear space dilations in prion-infected mice and identifies TRPV2 as a contributor to this phenomenon, which may relate to spongiform degeneration.

3 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceInternational Journal of Molecular SciencesPeer-reviewedNov 26, 2022

Identification of a cardiac glycoside exhibiting favorable brain bioavailability and potency for reducing levels of the cellular prion protein

Shehab Eid, Thomas Zerbes, Declan Williams…·Gerold Schmitt‐Ulms

12 citations

humanstatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 26, 2022

Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation in a neprilysin-independent manner

Declan Williams, Bei Qi Yan, Hansen Wang…·Gerold Schmitt‐Ulms

This study shows that somatostatin reduces Aβ plaque formation in aged mice by inhibiting Aβ aggregation, independent of neprilysin.

1 citation

mouseexperimental assay

𝕏 PostBluesky