Integrated genetic screening reveals FEN1 as a driver of stemness and temozolomide resistance in glioblastoma
Benjamin A. Brakel, Dillon McKenna, Anish Puri, Vaseem Muhammad Shaikh, Manoj Pratap Singh, Ali Jason Saleh, Abdo-jose Tomajian, Nicholas Mikolajewicz, Marcello Beltrami, Alisha Anand, Petar Miletic, Kevin R. Brown, David D. Tieu, William Thomas Maich, Sabra Khalid Salim, , Sheila Kumari Singh
This study identifies FEN1 as a driver of glioblastoma stem cell survival and temozolomide resistance, showing FEN1 inhibition can enhance TMZ efficacy in aggressive tumors.
bioRxiv · Jun 18, 2025 · PreprintCancer Biology