Author

Nicholas Mikolajewicz

Great Ormond Street HospitalORCID 0000-0002-7525-0384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jason MoffatiD· 3 shared Kevin R. BrowniD· 3 shared David D. TieuiD· 2 shared Abdo-jose TomajianiD· 1 shared Adrian DraziciD· 1 shared Adrian Granda FariasiD· 1 shared Ali Jason SalehiD· 1 shared Alisha AnandiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersSystems Biology

Jason MoffatORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Zernab Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine Chan, Amy H.Y. Tong, Carles Pons, Henry N. Ward, Catherine Ross, Jolanda S. van Leeuwen, Michael Aregger, Keith A. Lawson, Barbara Mair, , Charles M. Boone

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

bioRxiv · Jun 30, 2025 · PreprintSystems Biology

Integrated genetic screening reveals FEN1 as a driver of stemness and temozolomide resistance in glioblastoma

Benjamin A. Brakel, Dillon McKenna, Anish Puri, Vaseem Muhammad Shaikh, Manoj Pratap Singh, Ali Jason Saleh, Abdo-jose Tomajian, Nicholas Mikolajewicz, Marcello Beltrami, Alisha Anand, Petar Miletic, Kevin R. Brown, David D. Tieu, William Thomas Maich, Sabra Khalid Salim, , Sheila Kumari Singh

This study identifies FEN1 as a driver of glioblastoma stem cell survival and temozolomide resistance, showing FEN1 inhibition can enhance TMZ efficacy in aggressive tumors.

bioRxiv · Jun 18, 2025 · PreprintCancer Biology

Multi-level cellular and functional annotation of single-cell transcriptomes

Nicholas Mikolajewicz, Kevin R. Brown, Jason Moffat, Hong Ryul Han

The paper introduces scPipeline, a tool for multi-level cellular and functional annotation of scRNA-seq data, validated across diverse datasets.

bioRxiv · Mar 13, 2022 · PreprintBioinformatics