Murepavadin is a broad-spectrum outer membrane permeabiliser
Vedang S Deshpande, Sarah K T Titcombe, Shen Li, Sophia M A Riley, Edward J. A. Douglas, Andrew M. Edwards
This study shows murepavadin disrupts outer membranes of Gram-negative bacteria, increasing susceptibility to antibiotics and host defenses.
bioRxiv · Jun 11, 2026 · PreprintMicrobiology