Andrew M. Edwards

A novel ciprofloxacin analogue enables daptomycin-mediated killing of resistant Staphylococcus aureus by increasing septum formation

The paper shows that IMP-1700, a ciprofloxacin analogue, increases septum formation in S. aureus, enhancing daptomycin's effectiveness against resistant strains.

Commonly prescribed medicines antagonise anti-MRSA antibiotics and select for resistance

This study identifies three non-antibiotic medicines that inhibit MRSA growth and antagonize anti-MRSA antibiotics, promoting resistance development.

Murepavadin is a broad-spectrum outer membrane permeabiliser

This study shows murepavadin disrupts outer membranes of Gram-negative bacteria, increasing susceptibility to antibiotics and host defenses.

Polymyxin heteroresistance in Klebsiella oxytoca

This study identifies polymyxin B heteroresistance in Klebsiella oxytoca clinical isolates, showing a 16-fold resistance variation between subpopulations.

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.

Acquisition of daptomycin resistance in patients results in decreased virulence in Drosophila

This study shows that daptomycin resistance in Staphylococcus aureus reduces its virulence in Drosophila by increasing susceptibility to prophenoloxidase, not through reduced toxin production or immune evasion.

Polymyxin B lethality requires energy-dependent outer membrane disruption

This study shows that polymyxin B lethality requires energy-dependent outer membrane disruption and depends on metabolic activity and LPS synthesis.