Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription
Ashley P. E. Roberts, Anne Orr, Victor Iliev, Lauren Orr, Steven McFarlane, Zhousiyu Yang, Ilaria Epifano, Colin Loney, Milagros Collados Rodríguez, Anna Ruth Cliffe, Kristen L. Conn, Chris Boutell
This study identifies Daxx-mediated histone H3.3 deposition on HSV-1 DNA as a host restriction factor that limits genome decompaction and immediate-early transcription.
PLoS Pathogens · Aug 20, 2025Peer-reviewedMicrobiology